Evolution of nutritional status and associated factors in formula-fed infants with cow’s milk protein allergy
provided

Name: GIULIANA RIZZO TAVEIRA

Publication date: 19/12/2022
Advisor:

Name	Role
CAROLINA PERIM DE FARIA	Co-advisor *
MIRIAM CARMO RODRIGUES BARBOSA	Advisor *

Examining board:

Name	Role
CAROLINA PERIM DE FARIA	Co advisor *
FABIANO KENJI HARAGUCHI	Internal Alternate *
FABÍOLA LACERDA PIRES SOARES	Internal Examiner *
MIRIAM CARMO RODRIGUES BARBOSA	Advisor *

Summary: Introduction: Cow`s milk protein allergy (CPMA) is a common allergy in infants and can affect proper growth and development. Objective: To evaluate and verify factors associated with the evolution of the nutritional status (NS) of infants with cow’s milk protein allergy (CPMA) who were fed with hypoallergenic formulas (HF). Methods: This is a longitudinal study with infants (n=1036) provided by a governmental program in Brazilian. Nutritional status was assessed before (T1) and after (T2) treatment with HF. The causality of exposure variables on the evolution of NS was verified by Multinomial Logistic Regression (MLR). Results: We observed an increase in anthropometric indexes analyzed with statistically significant results (p<0.01). The weight/age and height/age showed a significant reduction in infants with nutritional deficit. The Body Mass
Index (BMI) showed a decrease in the number of infants with nutritional
deficit (<-2 z-score). On the other hand, there was an increase in those
classified as at possible risk of overweight, overweight and obese. MLR
showed that who remained <12months in the program had a lower odds ratio (95% CI=0.355–0.906;p=0.018) to have inadequate NS with increasing BMI. Preterm infants were 4 times more likely (CI 95%=1.520–10.694;p=0.005) to have their BMI decreased and those who received nutritional counseling had a lower odds ratio (CI 95% =0.411–0.953;p=0.029) to maintain adequate NS.
Conclusion: The program has a significant impact on the NS of infants with
CPMA. The constant management and implementation of differentiated criteria
according to the evolution of NS for the supply of HF is fundamental in the
development of public policy.

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