Mineral and Bone Disorder of Chronic Kidney Disease, Nutritional Status, and Associated Factors: A Study in Hemodialysis
Patient
Name: FERNANDA ZOBOLE PETERLE
Publication date: 21/06/2024
Examining board:
Name |
Role |
|---|---|
| LUCIANE BRESCIANI SALAROLI | Presidente |
| MIRIAN PATRÍCIA CASTRO PEREIRA PAIXÃO | Examinador Externo |
| TAMIRES DOS SANTOS VIEIRA | Examinador Interno |
Summary: Chronic kidney disease is closely related to Chronic Kidney Disease-Mineral and
Bone Disorder, resulting in distinct nutritional contexts. This study aimed to evaluate
the laboratory constituents of Chronic Kidney Disease-Mineral and Bone Disorder,
along with clinical, sociodemographic, and nutritional factors in hemodialysis patients
in the Greater Vitória Metropolitan Region. This cross-sectional study included 790
hemodialysis patients (58% men) with a mean age of 54.23 years. Chronic Kidney
Disease-Mineral and Bone Disorder was assessed using specific diagnostic criteria.
Sociodemographic tools, lifestyle habits, clinical characteristics, anthropometric
measures, and other laboratory variables were utilized. The odds of individuals
having altered ionized calcium increased in the absence of employment (OR:1.50)
and with an income below the minimum wage (OR:2.00). Alcoholism (OR:1.40) and a
significantly increased waist circumference (OR:3.04) increased the chances of
altered vitamin D levels. Elderly individuals (OR:2.04) showed a higher chance of
altered phosphorus levels. Being male (OR:0.61), having higher education (OR:0.84),
and maintaining the thickness of the adductor pollicis muscle (OR:0.58) reduced the
chances of altered phosphorus levels. Black individuals (OR:0.54) showed lower
chances of altered parathyroid hormone levels, while those with higher interdialytic
weight gain (OR:1.01) showed higher chances of altered parathyroid hormone levels.
Parathyroid hormone and dialysis time showed a moderate positive correlation
(r:0.582, p <0.001). Phosphorus levels had a moderate positive correlation with
potassium (r:0.556, p 0.020) and a negative correlation with age (r:-0.413, p 0.036).
Vitamin D levels had a positive correlation with adductor pollicis muscle thickness
(r:0.602, p 0.018) and right-hand grip strength (r:0.402, p <0.001), and a negative
correlation with waist circumference (r:-0.600, p 0.020) and arm muscle area (r:-
0.769, p 0.024). Ionized calcium indices had a strong positive correlation with the
duration of replacement therapy (r:0.961, p 0.015) and a strong negative correlation
with body mass index (r:-0.82, p 0.046).
